Therapeutic Tolerance Workshop 26-28 June 2013

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Therapeutic Tolerance Workshop 26-28 June 2013

In June 2013 we will host the third international workshop on Clinical Therapeutic Tolerance.  The first, in June 2005 was entitled ‘Therapeutic Tolerance: Myth or Reality?’  In 2009 we entitled our workshop ‘Therapeutic Tolerance: Closer to Reality?’  For 2013 we have put together a further exciting programme, when we can start to discuss our attempts to induce and to measure therapeutic tolerance in the clinic. We have invited speakers from across the autoimmunity, transplantation and allergy fields and our provisional programme is attached.


The Third Newcastle Therapeutic Tolerance Workshop

26th-28th June 2013, Newcastle upon Tyne


Wednesday 26th June – Research Beehive, Newcastle University

Wednesday morning – delegates arrive for registration


Session 1-   Tolerance Mechanisms                            
Dan Littman (New York, USA) The Microbiome and Tolerance
Georg Holländer   (Oxford, UK) Central   Tolerance Mechanisms
Steve Cobbold (Oxford, UK) Peripheral Tolerance Mechanisms
Alan Mowatt   (Glasgow, UK) Mucosal Tolerance Mechanisms
Session 2-   Tolerance Mechanisms                            
Peter Krammer (Heidelberg, Germany) Apoptosis   and therapeutic tolerance
Steve Anderton   (Edinburgh, UK) Tolerance   and autoimmunity – interrogating the players
Anne Cooke (Cambridge,   UK) Tolerance   breakdown in murine diabetes
Iain McInnes   (Glasgow, UK) Investigating   immune tolerance – a systems biology approach
Buffet dinner   (Great North Museum)

Thursday 27th June – Research Beehive, Newcastle University

Session 3- Cells   and the maintenance of tolerance                           
Ethan Shevach (Maryland, USA) Regulatory   T Cells
Simon Fillatreau (Berlin, Germany) B Cells and   tolerance
Herman   Waldmann (Oxford, UK Cellular metabolism and tolerance
Chris Buckley (Birmingham,   UK) The   role of the stroma in immune tolerance
Matthew Collin (Newcastle, UK) Skin   dendritic cells and graft versus host disease
Session 4 – Immune modulating strategies in the   clinic
Lucienne Chatenoud (Paris, France) Anti-CD3   Therapy to Induce Tolerance
Joanna Jones (Cambridge, UK) Depletional   tolerance in multiple sclerosis
Thomas Wekerke (Vienna, Austria) Costimulation   blockade in man, mechanisms and outcomes
Michael Ehrenstein (London, UK) Manipulating   cytokines to induce tolerance
Session 5 – Immune modulating strategies in the   clinic
David Wraith (Bristol, UK) Peptide   Induced Tolerance
Mark Larche (Ontario,   Canada) Peptide   therapy of allergy with a focus on response biomarkers
Berent Prakken (Utrecht Netherlands) Heat   shock proteins and tolerance
Jacob van Laar (Newcastle, UK) Autologous   stem cell transplantation
Sir Roy Calne (Cambridge,   UK) Prope   tolerance – how near can we get?
Dinner (The Life   Centre)

Friday 28th June – Research Beehive, Newcastle University


Session 6 – Maximising clinical benefits of   tolerogenic therapies
Andrew Mellor (Georgia,   USA) Indoleamine dioxygenase and tolerance
Robert Lechler (London, UK) Biomarker   of tolerance induction
Andrew Cope (London,   UK) Can   we define a true remission state in RA?
Alberto Sanchez-Fueyo (London, UK) Iron   metabolism and transplantation tolerance
John Isaacs (Newcastle, UK) Getting   the timing right
David Wofsy (California,   USA) Designing   a therapeutic tolerance trial
Session 7 – Tolerogenic dendritic cells
Ranjeny Thomas (Brisbane, Australia) Tolerogenic   DCs in rheumatoid arthritis
Catharien Hilkens (Newcastle, UK) AuToDeCRA
Angus Thomson (Pittsburgh, USA) Tolerogenic   dendritic cells in transplantation
Session 8 – Cellular Therapies
Kathryn Wood (Oxford, UK) Regulatory   T cell in transplantation
Giovanna Lombardi (London, UK) Optimising   therapy with regulatory T cells
David Klatzmann (Paris,   France) Interleukin-2   and regulatory T cell expansion
Alan Tyndall   (Basel, Switzerland) Mesenchymal Stem Cells – The Holy   Grail
Closing remarks


Poster Presentations

Abstract submission deadline 14th March 2013 For those wishing to submit a poster presentation, please provide a 350 word abstract (no more than 1 side of A4), with up to 1 figure or table and include subheadings (Objectives, Methods, Results, Discussion).

Abstracts should be sent to (you will hear before the end of March whether your abstract has been accepted).

For further information please contact Lisa Tait ( or to register please visit our webstore at

Places are limited so please make sure you register soon to avoid disappointment.

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